Leonine Facies in Carcinoid Syndrome

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[Leonine facies in carcinoid syndrome].

Carcinoid syndrome is a rare disorder caused when elevated levels of vasoactive substances secreted by a carcinoid tumor fail to be metabolized by the liver. This can occur for a variety of reasons including metastatic invasion of the organ. Carcinoid syndrome results in elevated levels of 5-hydroxyindoleacetic acid in the urine. Clinical manifestations include: flushing, diarrhea, bronchospasm...

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Leukaemia cutis presenting as leonine facies.

Acute leukaemia may rarely present as diffuse papules, nodules and plaques forming leonine facies. Leukaemia cutis generally carries a poor prognosis, and responds less well to chemotherapy. We described a case of acute myelomonocytic leukaemia presenting as leonine facies as a result of extensive cutaneous infiltration. The patient did not achieve haematological remission following standard in...

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Multiple Familial Trichoepitheliomas Presenting as Leonine Facies

Trichoepithelioma is a benign tumor of follicular unit. It has been rarely described as the cause of leonine facies. We are presenting a classical case of multiple familial trichoepitheliomas (MFTs) with characteristic histopathological features leading to leonine facies.

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A patient with leonine facies and occult lung disease.

velvety hyperpigmentation in the neck ( fig. 2 ), axillae and the groin. Furthermore, the dorsa of the hands had brown thickened skin with a pebbly appearance ( fig. 3 ) and the palms showed rugose thickening with more pronounced skin markings ( fig. 4 ). His general and systemic clinical examination was otherwise unremarkable. What are the clinical diagnoses and, more importantly, which pulmon...

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Sezary syndrome presenting with leonine facies and treated with low-dose subcutaneous alemtuzumab.

Cutaneous T-cell lymphomas (CTCL) comprise a group of diseases characterized by the accumulation of malignant T cells within the skin. Sezary syndrome represents an aggressive form of CTCL, in which the skin is diffusely affected and the peripheral blood is involved. It is characterized by the triad of generalized erythroderma, lymphadenopathy, and neoplastic T cells (Sezary cells) in the skin,...

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ژورنال

عنوان ژورنال: Actas Dermo-Sifiliográficas (English Edition)

سال: 2010

ISSN: 1578-2190

DOI: 10.1016/s1578-2190(10)70839-8